Speaker 2: Claes Wahlestedt, USA
نویسنده
چکیده
The serotonin 2A receptor is one of the most abundant serotonin receptors in the human CNS and is a target for drugs designed to treat psychiatric disorders (McCorvy and Roth, 2015). Significantly, levels of serotonin 2A receptors have been shown to be altered in the CNS of subjects with schizophrenia (Dean, 2003), major depressive disorders (Arora and Meltzer, 1989; Dean et al., 2014) and suicide completers (Mann et al., 1986; Dean et al., 2014). These finding raise the issue of whether or not changes in levels of the serotonin 2A receptor s are involved in a drive to suicide or are changed in the CNS of suicide completers because they have suffered from disorders such as schizophrenia or major depressive disorders in which there are changed levels of the receptor. In this presentation the current literature on changes in serotonin 2A receptors, as measured by neuroimaging and postmortem CNS studies, will be reviewed in the context of unravelling the role of these changes in the aetiology of psychiatric disorders versus a drive to suicide completion. In addition, the growing understanding of the regulation of levels of serotonin 2A receptors in the CNS will be discussed within the framework of understanding how changes in the receptors may have a role in the aetiologies of psychiatric disorders and their involvement in a drive to suicide.
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⁎ Corresponding author at: Center for Therapeutic Innov atry & Behavioral Sciences, University of Miami Miller Sc 10th Ave, BRB-648 (M-860) Miami, FL 33136, USA. Tel.: + E-mail addresses: [email protected] (C.-H. Vol [email protected] (C. Wahlestedt). 1 Tel.: +1 305 243 7694. http://dx.doi.org/10.1016/j.nepig.2014.10.002 2214-7845/© 2014 The Authors. Published by Elsevier Inc Articl...
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